What pathogen should be targeted in the treatment of increased coughing and wheezing in a 13-year-old male with cystic fibrosis?

In a patient with cystic fibrosis, particularly one experiencing increased coughing and wheezing, Pseudomonas aeruginosa is the most pertinent pathogen to target in treatment. Cystic fibrosis leads to thick, viscous mucus production in the lungs, creating an environment that is conducive to chronic infections. Pseudomonas aeruginosa is an opportunistic pathogen that is commonly associated with lung infections in individuals with cystic fibrosis due to its ability to thrive in such a thick mucus environment.

This organism is often implicated in the recurrent pulmonary infections that characterize the disease, and it can be particularly difficult to eradicate once established in the lungs. Therefore, targeting Pseudomonas aeruginosa is essential for managing the respiratory complications associated with cystic fibrosis, especially in cases where the patient presents with increased respiratory symptoms such as coughing and wheezing.

The other pathogens listed have less relevance in this context. Pneumocystis jiroveci is mainly associated with immunocompromised individuals, and Mycoplasma pneumoniae tends to be more common in younger populations, such as school-aged children, but is not specifically associated with cystic fibrosis. Haemophilus influenzae can cause respiratory infections, but it is not the most significant concern in the